FIGURE

FIGURE 4

ID

ZDB-FIG-250322-4

Publication

Le et al., 2025 - A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression

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FIGURE 4

DIC microscopy of control and crim1^−/− larvae that are homozygous for a 2 base pair deletion, c.339_340delCT p.Leu112Leufs*3, at 3 days post fertilization (dpf). (A–C) Lenses from control larvae and a crim1^−/− larva that have a smooth and regular appearance. (D–F) Lenses from crim1^−/− larvae that have a roughened and irregular appearance. (G) Method for obtaining measurements of lens diameter. (H) Measurements of lens diameter (in μm) in control and crim1^−/− larvae in 16 lenses. There is a significant reduction in lens diameter for the crim1^−/− larvae compared to controls (P = 0.036).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	crim1^s4007/s4007 (EKW)
Observed In:	lens
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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