FIGURE

FIGURE 6

ID

ZDB-FIG-250322-6

Publication

Le et al., 2025 - A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression

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FIGURE 6

Phospho-histone H3 and 5-bromo-2′-deoxyuridine staining in control, crim1^+/− larvae, and crim1^−/− larvae that are homozygous for a 2 base pair deletion, c.339_340delCT p.Leu112Leufs*3, at 48 and 72 h post fertilization (hpf). Representative sections of eyes from control larvae (A, D, G), crim1^+/− larvae (B, E, H), and crim1^−/− larvae (C, F, I) stained with the PH3 antibody (Alexa Fluor 488 dye; green) and DAPI (merged (A’–F’), blue) at 48 and 72 hpf (A–F) and with BrdU (Alexa Fluor 488 dye; green) and DAPI (merged (G’–I’), blue) at 48 hpf (G–I). The quantification of the BrdU antibody showed a significant reduction in BrdU staining in the homozygous crim1^−/− larvae compared to control at 48 hpf (P = 0.013). L = lens.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	crim1^s4007/s4007 (EKW)
Observed In:	eye cell population proliferation
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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