FIGURE

FIGURE 9

ID

ZDB-FIG-250322-9

Publication

Le et al., 2025 - A zebrafish model of crim1 loss of function has small and misshapen lenses with dysregulated clic4 and fgf1b expression

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FIGURE 9

RT-qPCR showing significant downregulation of crim1, clic4, and itgb1 and significant upregulation of serpinb1l2 and fgf1b. (A) RT-qPCR showing expression of crim1, clic4, and itgb1 in crim1^−/− larvae compared to controls. RT-qPCR was performed on dissected eyes for all experiments from control (white columns; expression normalized to 1.0) and crim1^−/− larvae (black columns) at 72 hpf. The results show significantly reduced expression of crim1 (P = 0.04), clic4 (P = 0.02), and itgb1 (P = 0.02) in crim1^−/− larvae compared to controls. (B) RT-qPCR showing expression of serpinb1l2, fgf1b, and gpib in crim1^−/− larvae compared to controls. The results show significantly increased expression of serpinb1l2 (P = 0.02) and fgf1b (P = 0.02) but not gpib (P = 0.25) in crim1^−/− larvae compared to controls. (C) RT-qPCR showing expression of bzw1a and nampta in crim1^−/− larvae compared to controls. The results do not show significantly reduced expression for bzw1a (P = 0.4) or nampta (P = 0.16) in crim1^−/− larvae compared to controls.

Expression Data

Genes:	bzw1a clic4 crim1 fgf1b gpib itgb1b nampt1 serpinb1l2
Fish:	EKW crim1^s4007/s4007 (EKW)
Anatomical Term:	eye
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	crim1^s4007/s4007 (EKW)
Observed In:	eye
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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